An experimental study on the nanosecond laser processing of the spiral groove on the dry gas seal rotational ring surfaces made of GH4169 was carried out. Orthogonal tests and one-factor methods were utilized to reveal the effects of laser power, scanning speed, filling spacing and repetition frequency on the spiral groove depth and bottom roughness Ra, and to determine the appropriate combination of laser processing parameters. The results show that the greatest influence on the depth of the spiral grooves on the surfaces of GH4169 alloy is the laser power, followed by the repetition frequency and the scanning speed, and the greatest influence on the roughness of the groove bottoms is the scanning speed, followed by the repetition frequency and the scanning spacing. With the laser power of 18 W, scanning speed of 40 mm/s, fill spacing of 0.005 mm, and repetition frequency of 50 kHz, the spiral grooves on the machined rotational ring surfaces is able to meet the machining requirements of groove depth of 7 μm, and groove bottom roughness of Ra≤0.8 μm.