China Mechanical Engineering ›› 2022, Vol. 33 ›› Issue (23): 2844-2850.DOI: 10.3969/j.issn.1004-132X.2022.23.008

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Design and Manufacture Method of Bionic Porous Structures for Orthopedic Implants

JIAO Chen1;CHAO Long1;ZHU Lei1;SHEN Lida1;LIANG Huixin2;DAI Ning1;WANG Changjiang3;SUN Jun4   

  1. 1.College of Mechanical and Electronic Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing,210016
    2.Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing,210008
    3.University of Sussex,Brighton,United Kingdom,BN1 9RH
    4.Adverse Drug Reaction Monitoring Center of Jiangsu Province,Nanjing,210002
  • Online:2022-12-10 Published:2022-12-27

面向骨科植入物的仿生多孔结构设计与制造方法

焦晨1;晁龙1;朱磊1;沈理达1;梁绘昕2;戴宁1;王长江3;孙骏4   

  1. 1.南京航空航天大学机电学院,南京,210016
    2.南京大学医学院附属鼓楼医院,南京,210008
    3.萨塞克斯大学,布莱顿,英国,BN1 9RH
    4.江苏省药品不良反应监测中心,南京,210002
  • 通讯作者: 沈理达(通信作者),男,1979年生,教授、博士研究生导师。研究方向为增材制造、生物制造、仿生制造。发表论文160余篇。E-mail:ldshen@nuaa.edu.cn。
  • 作者简介:焦晨,男,1994年生,博士研究生。研究方向为陶瓷材料的增材制造工艺。发表论文14篇。E-mail:jiaochen@nuaa.edu.cn。
  • 基金资助:
    国家重点研发计划(2018YFB1105400,2018YFB1105801);江苏省科技厅重点研发计划(BE2019002)

Abstract: The selective laser melting and ceramic digital light processing methods were adopted to fabricate metal scaffolds and ceramic scaffolds with porous structures. The compression test was employed to evaluate the mechanics behaviors of the scaffolds. The in vitro cultivation of MC3T3E1 cells was used to evaluate the biocompatibility of the scaffolds. The test results show that the irregularity and porosity are influential to the mechanics properties and biocompatibility; metal scaffolds have better mechanics properties, while ceramic scaffoldsis are closer to the cancellous bones; the irregular pores show better performance of cell adhesion which improves the biocompatibility of the scaffolds. 

Key words:  , scaffold, additive manufacturing, porous structure, mechanics property, biocompatibility

摘要: 采用激光选区熔化及陶瓷光固化技术制备了具有多孔特征的金属骨支架与陶瓷骨支架,采用压缩试验评价了两种骨支架的力学性能,采用体外培养MC3T3-E1细胞的方式评估了骨支架的生物相容性。研究结果表明,支架不规则度和孔隙率的变化均会影响支架的力学性能与生物性能;金属支架具有更优良的力学性能,陶瓷支架具有更接近松质骨的力学性能;不规则孔隙有助于细胞附着,使骨支架具有更好的生物相容性。

关键词: 支架, 增材制造, 多孔结构, 力学性能, 生物相容性

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