The effects of axle load and curve radius on total slippage of contact particles and friction work of wheel/rail were investigated with numerical methods .Comparing with the date of rail wear volume tested by simulation experiments, it is indicated that axle load and curve radius are the important factors to effect rolling contact wear of wheel/rail, and there is a linear relationship between rail wear volume and friction work of wheel/rail. The preliminary empirical formula between wear volume of rail sample and friction work is given by analysing the experimental and calculation results, the formula offers a certain reference value for researching wear of wheel/rail and predicting wear volume of rail.