电磁驱动式无针注射器设计及力学和运动仿真

摘要/Abstract

摘要： 针对目前广泛使用的机械式和气动式无针注射器存在的不能持久使用和结构笨重等缺点，设计了基于使用直流电电源的电磁驱动无针注射装置，介绍了一种新的设计方案。将电磁式无针注射系统按电磁动力部分和流体部分分别建立数学模型，推导出相应的公式。分别对电磁动力部分及流体部分进行仿真分析，绘制了电流、铁芯相对位置及其所受电磁力大小的关系图，安瓿杆推力与喷射口压力、流体速度的关系图。结果表明：无针注射器的动力部分符合推力的设计要求，安瓿的喷射压力与射流速度达到了刺入人体表层皮肤的要求。

关键词: 无针注射, 直流电, 电磁力, 数学模型

Abstract: For heavy, unsustainable uses and other shortcomings of the widely used mechanical and pneumatic needle-free injectors, a needle-free injection was proposed by using an electromagnetic drive DC power supply devices; the electromagnetic needle-free injection systems were divided into electromagnetic portions and the fluid portions, and mathematical models were established to derive the corresponding formulas and numerical calculations. The electromagnetic forces and the fluid parts of the simulation analysis, the graph of the current, the relative position of the core and electromagnetic forces, and the diagram of ampoules thrust rod ejection outlet pressure and fluid velocity were obtained. The results show that: the needle free injector have enough power to meet the design requirements, ampoule injection pressure and speed of the jet meet the requirements of entering human skin surfaces.

Key words: needle-free injection, direct current, magnetic force, mathematical model

中图分类号:

TH122

陈添禹1;王明娣1;陈洁2. 电磁驱动式无针注射器设计及力学和运动仿真[J]. 中国机械工程.

CHEN Tianyu1;WANG Mingdi1;CHEN Jie2. Design of Needle Free Injectors Driven by Electromagnetism and Their Mechanics and Motion Simulations[J]. China Mechanical Engineering.

参考文献

[1]周旭,王伽伯,肖小河. 无针注射给药系统及应用[J]. 解放军药学学报,2005,21(6):439-443.
ZHOU Xu, WANG Jiabo, XIAO Xiaohe. Needle-free Injection System and Its Application[J]. Pharm. J Chin. PLA,2005,21(6):439-443.

[2]KOLHE S，SONTAKKE S. A Review on Needle Free Drug Deliver System.[J]. International Journal of Current Pharmaceutical Reseach,2013,5(2):6975-7066.

[3]TABERNER A J, BALL N B, HOGAN N C, et al. A Portable Needle-free Jet Injector Based on a Custom High Power-density Voice-coil Actuator[C]// International Conference of the IEEE Engineering in Medicine & Biology Society.New York,2006:5001-5004.

[4]贾君鹏. 无针注射器结构创新设计[D].苏州：苏州大学，2011.
JIA Junpeng. Innovation Design of the Needle-free Injector[D]. Suzhou: Soochow University,2011.

[5]ZSIGMOND E K, DARBY P, KOENIG H M, et al. Painless Intravenous Catheterization by Intradermal Jet Injection of Lidocaine: a Randomized Trial[J]. Journal of Clinical Anesthesia, 1999,11(2):87-94.

[6]WILLIAMS J, FOX-LEYVA L, CHRISTENSEN C, et al. Hepatitis a Vaccine Administration: Comparison between Jet-injector and Needle Injection[J]. Vaccine,2000,18(18):1939-1943.

[7]SCHRAMM J, MITRAGOTRI S. Transdermal Drug Delivery by Jet Injectors: Energetics of Jet Formation and Penetration[J]. Pharmaceutical Research,2002,19(11):1673-1682.

[8]SCHRAMM-BAXTER J, KATRENCIK J, MITRAGOTRI S. Jet Injection into Polyacrylamide gels: Investigation of Jet Injection Mechanics[J]. Journal of Biomechanics,2004,37(8):1181-1188.

[9]SHERGOLD O A, FLECK N A, KING T S. The Penetration of a Soft Solid by a Liquid Jet, with Application to the Administration of a Needle-free Injection[J]. Journal of Biomechanics,2006,39(14):2593-2602.

[10]SCHRAMM-BAXTER J, MITRAGOTRI S. Needle-free Jet Injections: Dependence of Jet Penetration and Dispersion in the Skin on Jet Power[J]. Journal of Controlled Release Official Journal of the Controlled Release Society,2004,97(3):527-535.

[11]朱洪强. 电磁枪械(磁阻型线圈式)的有关问题研究[D]. 南京：南京理工大学, 2007.
ZHU Hongqiang. Research on the Problems of Electromagnetic Guns (Reluctant Coil Type)[D]. Nanjing: Nanjing University of Science and Technology, 2007.

[12]应人龙. 基于喷射理论的无针注射系统建模及实验研究[D].杭州：浙江大学,2008.
YING Renlong. Modeling and Experimental Study of Needleless Injection System Based on Spouting Theory[D]. Hangzhou: Zhejiang University, 2008.

[13]陈波,汪洪丹, 吴健康,等. 无针注射器数值模拟和工作特性分析[J]. 中国机械工程,2008, 19(2):196-199.
CHEN Bo, WANG Hongdan, WU Jiankang, et al. Numerical Study and Working Behavior of Hypospray[J]. China Mechanical Engineering, 2008,19(2):196-199.

[14]彭睿. 无针注射器动力学仿真及其注射机理的研究[D]. 武汉：华中科技大学, 2009.
PENG Rui. Study on Dynamic Simulation of Needleless Syringe and Its Injection Mechanism[D]. Wuhan: Huazhong University of Science and Technology, 2009.

[15]冯利军. 电磁力驱动无针注射系统的研究[D]. 武汉：华中科技大学, 2012.
FENG Lijun. Research of a Needle-free Injection System Powered by Magnetic Force[D]. Wuhan: Huazhong University of Science and Technology, 2012.

[16]孙志涌. 精通MATLAB6.5[M].北京：北京航天航空大学出版社，2003.
SUN Zhiyong. Proficient in MATLAB6.5[M]. Beijing: Beihang University Press, 2003.

[17]罗建军.MATLAB教程[M]. 北京：电子工业出版社，2005.
LUO Jianjun. MATLAB Tutorial[M]. Beijing: Publishing House of Electronics Industry, 2005.

[18]彭睿. 无针注射器动力学仿真及其注射机理的研究[D].武汉：华中科技大学, 2009.
PENG Rui. Study on Dynamic Simulation of Needleless Syringe and Its Injection Mechanism[D]. Wuhan: Huazhong University of Science and Technology, 2009.