再生骨支架内部结构性能的综合评价

中国机械工程 ›› 2013, Vol. 24 ›› Issue (20): 2768-2774.

再生骨支架内部结构性能的综合评价

尤飞1;胡庆夕2;朱晓锦2

1.上海理工大学,上海,200093
2.上海大学,上海,200444

出版日期:2013-10-25 发布日期:2013-10-25
基金资助:
国家自然科学基金资助项目(51075253);上海理工大学博士启动基金资助项目(1D-13-309-007)
National Natural Science Foundation of China（No. 51075253）

Integrated Evaluation on Inner Structure Performance of a Regenerative Bone Scaffold

You Fei1;Hu Qingxi2;Zhu Xiaojin2

1.University of Shanghai for Science & Technology,Shanghai,200093
2.Shanghai University,Shanghai,200444

Online:2013-10-25 Published:2013-10-25
Supported by:

National Natural Science Foundation of China（No. 51075253）

摘要/Abstract

摘要：

在分析影响再生骨支架内部微观结构性能因素的基础上,构建了支架内部结构性能的综合评价指标体系。根据各项评价指标对支架的生物活性、力学强度、降解速度等性能的影响程度，建立支架内部结构性能的层次分析模型;基于层次分析法(AHP)理论和计算方法，确定各项评价指标在内部结构性能综合评价中的权重值。基于灰色关联度分析的评价理论，构建支架内部结构性能的综合评价模型;计算各项评价指标的灰色关联度值，以此综合评判支架内部结构性能的优劣，保证再生骨支架具有良好的生物活性、较好的力学性能以及均衡的降解速度。

关键词: 再生骨支架, 灰色关联度分析, 层次分析法, 综合评价模型

Abstract:

According to factors influencing the inner microstructure performance of a regenerative bone scaffold,an evaluation index system of inner microstructure of the
scaffold was constructed.Every evaluation index influencing bioactivity,biomechanical strength and degradation rate of scaffold was analyzed, and an analytic hierarchy
model of inner microstructure performance of scaffold was set up.The weight value of every evaluation index was calculated based on the theory of AHP.An integrated evaluation model of inner microstructure performance of the regenerative bone scaffold was constructed based on the theory of gray relation grade,and the gray relation value of every evaluation index was calculated to synthetically evaluate inner microstructure performance of the scaffold.The regenerative bone scaffold evaluated with this method
has good bioactivity,better mechanical properties and uniform degradation rate.

Key words: regenerative bone scaffold, grey related analysis, analytic hierarchy process(AHP), integrated evaluation model

中图分类号:

尤飞1;胡庆夕2;朱晓锦2. 再生骨支架内部结构性能的综合评价[J]. 中国机械工程, 2013, 24(20): 2768-2774.

You Fei1;Hu Qingxi2;Zhu Xiaojin2. Integrated Evaluation on Inner Structure Performance of a Regenerative Bone Scaffold[J]. China Mechanical Engineering, 2013, 24(20): 2768-2774.

参考文献

[1]李祥 [1],李涤尘 [1],王林 [2],卢秉恒 [1],王臻 [2].基于RP的骨组织工程支架构造及生物学特性分析[J].中国机械工程,2005,16(12):1117-1120.
[2]万蕾蕾[1],刘宏伟[1].β-磷酸三钙复合骨髓基质细胞构建组织工程骨的实验研究[J].口腔医学研究,2010,26(4):497-500.
[3]徐洋.表面改性的纳米羟基磷灰石/PLGA复合材料的制备及成骨活性实验研究[D].吉林大学,2010:
[4]胡帅[1],王嫣[1],陈小菊[1],周兰[2],陈文直[3].冰冻法构建三维海藻酸钠凝胶支架的实验研究[J].激光杂志,2010(2):67-68.
[5]李轶[1],冉炜[2],刘满珍[1],刘艳辉[1].新型骨组织工程支架复合重组人骨形态发生蛋白-2修复兔下颌骨缺损的实验研究[J].生物医学工程学杂志,2010(4):825-828.
[6]Kolambkar Y M, Dupont K M,Boerckel J D, et al.An Alginate — based Hybrid System for GrowthFactor Delivery in the Functional Repair of LargeBone Defects[J]. Biomaterials,2011,32(1) :65-74.
[7]Machado L M, Giehl I C’Nardi N B, et al. Evalua-tion of Scaffolds Based on a—Tricalcium PhosphateCements for Tissue Engineering Applications [J].IEEE Transactions on Biomedical Engineering,2011,58(6);1814-1819.
[8]Mozafari M, Moztarzadeh F. Novel Porous Gelatin/Bioactive Glass Scaffolds with Controlled PoreStructure Engineered via Compound Techniques forBone Tissue Engineering[C]//2011 1st Middle EastConference on Biomedical Engineering. Sharjah,U-nited Arab Emirates,2011,2 -.104-107.
[9]杨春蓉[1].骨组织工程支架研究现状及面临的问题[J].中国组织工程研究与临床康复,2009,13(8):1529-1532.
[10]汪焰恩[1,2],魏生民[1],闫秀天[2],陈垚[1],扬铭[1].图像分形法研究多孔骨支架微观形态[J].西安工业大学学报,2009,29(5):443-446.
[11]李国臣[1],王林[1],桑宏勋[1],李祥[2],王成焘[2],黄鑫[1],雷伟[1],姥伟[1].可控微结构EBM钛合金支架与成骨细胞的体外三维复合培养[J].中国矫形外科杂志,2009,17(24):1883-1887.
[12]刘婷.PHBV共混材料组织工程支架的研究[D].东华大学,2007:
[13]马哲一.骨组织工程支架内微流体流动状态的数值仿真及分析[D].燕山大学,2009:
[14]孟洁.组织工程支架拓扑结构及化学成分对细胞行为的影响 [D].中国协和医科大学,2007:
[15]赵茂俞[1,2],薛克敏[1],李萍[1].多目标质量的覆盖件成形工艺参数优化[J].机械工程学报,2009,45(8):276-282.
[16]杜栋,庞庆华,吴炎编著.现代综合评价方法与案例精选[M],2008:219.
[17]孙建军,成颖.定量分析方法[M].2版.南京:南京大学出版社,2005.
[18]尤飞[1],姚远[1],胡庆夕[1].仿生骨支架微观孔结构的构建与评价[J].机械工程学报,2011,47(1):138-144.